Once and Again Boutique
Thrift storeOnce and Again Boutique is a thrift store in Des Plaines, IL. You’ll find it at 50 E Nw Hwy, Des Plaines, IL 60016. It’s one of 3 secondhand and resale shops we track in Des Plaines.
The store keeps hours 5 days a week and is closed on Sunday, staying open as late as 5 PM on its longest days. Thrift hours change seasonally and around holidays, so a quick call before a long drive is worth it.
As a thrift store, its inventory is donated and priced for fast turnover: stock changes daily, sizes and styles are unpredictable, and the best finds go to shoppers who come back often rather than those who come once.
6 more secondhand shops are within driving distance, listed below, so it can anchor a longer thrifting circuit.

Store information
- Address
- 50 E Nw Hwy, Des Plaines, IL 60016
- Hours
- Monday: ClosedTuesday: 10:00 AM – 5:00 PMWednesday: 10:00 AM – 5:00 PMThursday: 10:00 AM – 5:00 PMFriday: 10:00 AM – 5:00 PMSaturday: 10:00 AM – 4:00 PMSunday: ClosedHours can change — call ahead to confirm.
- Phone
- +18477687055
Before you go
- Ask at the register which tag color is on sale this week and which is newest — the sale racks are cheap, the newest racks are where fresh donations land.
- Check garments under good light for stains and test every zipper; most thrift sales are final.
- Bring a tape measure and your key measurements — sizes vary wildly across eras and brands.
- It’s closed on Sunday — plan the visit for another day.
Thrift & secondhand stores near Des Plaines

The Salvation Army
Thrift store609 West Dempster Street, Des Plaines, IL1.6 mi
Monday - Friday 9:00 am to 4:00 pm

Arlington Heights Antiques
Antique store1723 E Central Rd, Arlington Heights, IL2.2 mi
Monday: Closed; Tuesday: Closed; Wednesday: 10:00 AM – 4:00 PM; Thursday: 10:00 AM – 5:00 PM; Friday: 10:00 AM – 5:00 PM; Saturday: 10:00 AM – 5:00 PM; Sunday: 10:00 AM – 4:00 PM

Goodwill
Thrift storeLee Street, Des Plaines, IL2.7 mi

Oakton Street Antique Center
Antique store2430 East Oakton Street, Arlington Heights, IL2.7 mi
Mo-Sa 10:00-18:00; Su 10:00-17:30

Just Unique
Secondhand store628 East Golf Road, Arlington Heights, IL2.8 mi
Tu-Fr 11:00-18:00; Sa 10:00-16:00

Prairie Interiors
Antique store10350 Dearlove Rd, Ste J1, Glenview, IL3.2 mi
Monday: 9:00 AM – 5:00 PM; Tuesday: 9:00 AM – 5:00 PM; Wednesday: 9:00 AM – 5:00 PM; Thursday: 9:00 AM – 5:00 PM; Friday: 9:00 AM – 5:00 PM; Saturday: Closed; Sunday: Closed
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Frequently asked questions
Where is Once and Again Boutique located?
Once and Again Boutique is located at 50 E Nw Hwy, Des Plaines, IL 60016.
What are Once and Again Boutique’s hours?
Listed hours: Monday: Closed; Tuesday: 10:00 AM – 5:00 PM; Wednesday: 10:00 AM – 5:00 PM; Thursday: 10:00 AM – 5:00 PM; Friday: 10:00 AM – 5:00 PM; Saturday: 10:00 AM – 4:00 PM; Sunday: Closed. Hours can change — call ahead at +18477687055 to confirm.
Is Once and Again Boutique open on Sunday?
No — Once and Again Boutique is closed on Sunday according to its posted hours.
What kind of store is Once and Again Boutique?
Once and Again Boutique is a thrift store in Des Plaines, IL.
Are there other thrift or secondhand stores near Once and Again Boutique?
Yes — we list 6 other secondhand, thrift, consignment, vintage, or antique stores within about 50 miles. See the nearby stores section on this page.
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Listing last updated from public listings and open map data.